IndraLab

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MDM2-C305F increases the amount of TP53. 2 / 2

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"The ability of mutant MDM2 C305F to promote tumorigenesis in a c-Myc-driven cancer model is caused by the inability of the RPL5/RPL11/5S rRNA complex to upregulate p53 levels."

36617563

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"Corroborating these data, expression of two additional p53 transcriptional target genes Phlda3 and Bax was increased on average 3.9- and 1.7-fold, respectively, in CFU-Es by Mdm2 C305F."

25987256

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IndraLab

Statements

MDM2-C305F increases the amount of TP53. 2 / 2

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