IndraLab

Statements

COPS5 decreases the amount of DKK1. 5 / 5
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"Here, we show that CSN5 suppresses DKK1 expression and secretion in CRC cells, thereby promoting WNT signaling."
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"Tumor formation experiments in vitro showed that the tumor size, microvessel density and VEGF expression of CRC cells with high expression of Dkk1 decreased, and that CSN5, miR-410 and HotTip could promote the progress of CRC by inhibiting the expression of Dkk1."
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"Interestingly, CSN5 knockdown increased intracellular DKK1 protein levels in SW480 cells."
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"A Recent study by the same team showed that Jab1/CSN5 suppresses WNT inhibitor DKK1 expression and secretion in colorectal cancer cells, thereby promoting Wnt signaling ( Jumpertz et al., 2017 )."
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"Jab1/CSN5 depletion affects Wnt signaling by downregulating β-catenin and increases the secretion of the Wnt inhibitor DKK1 in CRC cells ."
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