IndraLab

Statements

COPS5 decreases the amount of DKK1. 3 / 3
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"Tumor formation experiments in vitro showed that the tumor size, microvessel density and VEGF expression of CRC cells with high expression of Dkk1 decreased, and that CSN5, miR-410 and HotTip could promote the progress of CRC by inhibiting the expression of Dkk1."
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"Here, we show that CSN5 suppresses DKK1 expression and secretion in CRC cells, thereby promoting WNT signaling."
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"Interestingly, CSN5 knockdown increased intracellular DKK1 protein levels in SW480 cells."
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