IndraLab

Statements

OTUD4 activates NT5E. 3 / 3
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"Mechanistically, we have demonstrated that stabilization of CD73 catalyzed by OTUD4 suppresses cytotoxic CD8 T cell function, leading to tumor immune evasion."
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"These findings suggest OTUD4 may drive CD73 accumulation in TNBC (3)."
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"To determine if OTUD4 exerted a direct effect on CD73 turnover dynamics, we performed a pulse-chase assay in MDA-MB468 cells stably OE OTUD4 and found that overexpression of OTUD4 significantly slowed down CD73 protein turnover (Figure 2I)."
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