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Choline inhibits NLRP3. 2 / 2
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"However, substitution of extracellular Na + with choline did not impair K + efflux or NLRP3 activation elicited by ATP (XREF_FIG C), aerolysin, Al (OH) 3 and silica (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Eight-week aerobic endurance exercise and choline injection interventions upregulate myocardial M2AChR expression and inhibit MFN2, PERK, eIF-2α, ATF4, NLRP3, caspase-1, and IL-1β proteins in cardiomyopathic hypertrophied mice, which effectively attenuate myocardial ERS and inflammatory responses, thereby improving cardiac function (Ma M. et al., 2021)."
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