IndraLab

Statements

LIN28A binds USP28. 4 / 6
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sparser
"Specifically, the present study assessed whether RSV would disrupt the interactions between Lin28A and USP28 or prevents ERK1/2-mediated phosphorylation at S200."
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sparser
"These findings support the hypothesis that disruption of the Lin28A-USP28 interaction, which stabilizes Lin28A, could underlie the mechanism of RSV of reducing Lin28A protein expression levels at higher doses."
39397804
reach
"Specifically, the present study assessed whether RSV would disrupt the interactions between Lin28A and USP28 or prevents ERK1/2-mediated phosphorylation at S200.The MTT assay results in the present study agreed with previous reports (31,32), indicating that RSV inhibited NCCIT cell viability in a dose-dependent manner with an IC of 148 µM. All experiments were performed using the same concentrations (25–150 µM)."
39397804
sparser
"For example, Haq et al ( xref ) reported that Lin28A interacts with USP28 and deubiquitinates it, maintaining the protein stability and prolonging its half-life."
39397804