IndraLab

Statements

CSPalpha decreases the amount of KCNMA1. 4 / 4
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"While BK channel expression was reduced by CSPalpha, at low expression levels of BK channels, the CSPalpha mediated reduction was minimal."
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"Robust BK Channel Expression is Reduced by CSPalpha."
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"Quantification of these effects revealed that the CSPalpha chimeras - CSPalphaJD Hsp40 (17.0 +/-3.7%), CSPalphaJD Rdj2 (23.8 +/-2.0%) and CSPalphaJD Rme8 (17.5 +/-9.8%), along with wild-type CSPalpha (22.6 +/-3.4%) and the truncation mutant CSPalpha 1-82 (17.4 +/-8.1%), all produced a statistically significant and comparable reduction in BK channel expression."
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"We have found that CSPalpha, a presynaptic neuroprotective chaperone, acts to significantly limit BK channel current and BK channel expression."
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