IndraLab

Statements

USP19 activates CDKN1B. 3 / 4
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"Although p27 Kip1 mRNA levels remain unchanged upon USP19 depletion (XREF_FIG), it remains possible that p27 Kip1 synthesis is regulated also at the level of translation and that USP19 modulates such translational efficiency of p27 Kip1 mRNA."
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"Indeed, in cells transfected with USP19 siRNA p27 Kip1 levels remained relatively stable over time whereas the half-life of the protein was significantly lower in controls (XREF_FIG), implying that USP19 modulates the stability of p27 Kip1."
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"This increased p27 Kip1 induced by USP19 depletion did not appear to be due to increased gene transcription, as Northern blot analysis revealed that p27 Kip1 mRNA levels did not change (XREF_FIG)."
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