IndraLab
Statements
Tetrodotoxin inhibits SCN11A. 2 / 2
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2
reach
"The current subsets identified by TTX have been demonstrated to depend on specific voltage-gated sodium channels (VGSC): TTX-sensitive (TTX-S) sodium channels, such as Nav1.1, Nav.1.3, Nav1.6 and Nav1.7 which are blocked by TTX at nanomolar concentrations, and TTX-resistant (TTX-R) sodium channels, such as Nav1.8 and Nav1.9 which are blocked by TTX only at micromolar concentrations (Dib-Hajj et al., 2009)."
reach
"The voltage gated sodium channel family is comprised of ten members : SCN1A (Nav1.1), SCN2A (Nav1.2; SCN2A1 in mouse), SCN3A (Nav1.3), SCN4A (Nav1.4), SCN8A (Nav1.6), and SCN9A (Nav1.7) are blocked by tetrodotoxin, whereas SCN5A (Nav1.5), SCN7A (Nax), SCN10A (Nav1.8), and SCN11A (Nav1.9) are not blocked by tetrodotoxin [XREF_BIBR, XREF_BIBR, XREF_BIBR]."