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USP5 increases the amount of CTNNB1. 7 / 7
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"Furthermore, this correlation could be observed in tumor xenografts, with immunostaining of paraffin tissue sections showing that USP5 silencing caused a reduction in β-catenin expression (Fig. 4F)."
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"First, we found that USP5 silencing caused a reduction in β-catenin expression at the protein level but not at the mRNA level in CL1-5 cells (Fig. 4B and Additional file 1: Figure S5B) In addition, the similar results could be observed in H23, H522, and H1299 lung cancer cells (Additional file 1: Figure S5C)."
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"Overexpression of USP5 caused upregulation of β-catenin expression (Fig. 4C)."
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"USP5 has been reported to be expressed in two isoforms, and we found that both isoforms of USP5 were able to promote the expression of β-catenin (Fig. 4D)."
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"Moreover, USP5 knockdown suppressed Wnt-induced β-catenin expression (Fig. 4E)."
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"In the experiments of overexpression, USP5 promoted the proliferation of trophoblast cells, and up-regulated the expressions of beta-catenin and the downstream signals c-Myc and Cyclin D1 in trophoblast cells."
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"In trophoblast cells, USP5 up-regulates the expression of β-catenin and its downstream signals c-Myc and CCND1, promoting the proliferation of trophoblast cells [ 32 ]."
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