IndraLab

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Nitric oxide inhibits RELA. 13 / 13
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"Second, we find that NO represses NF-kB signaling, and prevents prolonged nuclear RelA localization."
28754681
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"Electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) assays further demonstrate that the p65 subunit of NF-kappaB and not p50 binding is specifically decreased by NO treatment."
16539692
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"In addition, MS-275 and SAHA suppressed lipopolysaccharide (LPS)-induced NF-kappaB p65 nuclear accumulation, IL-6, IL-18 and nitric oxide (NO) secretion as well as down-regulated pro angiogenic VEGF and MMP-2 and MMP-9 production in E11 cells at sub-micromolar levels."
20421217
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"High NO concentrations after iNOS stimulation inhibit protein adhesion expression on endothelial cells due to S-nitrosylation of p50 and p65 in NF-κB and IKKβ (Aguilar et al., 2020)."
34276407
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"NO promoted p65 S nitrosylation reduces p65 mediated transactivation of the NIS promoter in response to TSH stimulation."
26587909
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"For example, NO 2 -FAs inhibit NFkB activity by nitroalkylating the p65 subunit, thereby suppressing NFkB mediated pro inflammatory cytokine and adhesion protein expression [XREF_BIBR]."
19857569
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"We experimentally validated this bioinformatic prediction, and found that the p65 and RelA subunit of NF-kB is inhibited by NO production during IFN-gamma activation of M. tuberculosis infected macrophages."
28754681
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"We experimentally validated this bioinformatic prediction, and found that the p65 and RelA subunit of NF-kB is inhibited by NO production during IFN-gamma activation of M. tuberculosis infected macrophages."
28754681
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"Serum starvation also induces NOS2 derived NO; modulation of RelA by NO was verified in serum starved MB-468 cells in the presence and absence of both the NOS inhibitor l-NAME (N G -nitro-l-arginine methyl ester) and DETA/NO (XREF_SUPPLEMENTARY)."
29087320
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"Our experiments indicate that NO mediates S nitrosylation and inhibits NF-kappaB p65 activation in the brain of infected mice."
26915097
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"In addition, MS-275 and SAHA suppressed lipopolysaccharide (LPS)-induced NF-kappaB p65 nuclear accumulation, IL-6, IL-18 and nitric oxide (NO) secretion as well as down-regulated pro angiogenic VEGF and MMP-2 and MMP-9 production in E11 cells at sub-micromolar levels."
20421217
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"NO exposure also caused significant reductions of cytosol fraction p65 and p52 content in PAEC."
10516220
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"Taken together, our results suggested that sauchinone could inhibit production of NO in LPS stimulated RAW264.7 cells through the suppression of NF-kappaB by inhibiting transactivation activity of RelA subunit."
14750024