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USP2 activates INS. 3 / 3
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"Ubiquitin specific peptidase 2 (USP2) expression is decreased in patients with type 2 diabetes and mouse models of diabetes-induced muscle atrophy.USP2 can enhance insulin sensitivity and improve muscle mass and function in diabetic mice.USP2 stabilizes PPAR-gamma via deubiquitination to regulate muscle atrophy, uncovering a key mechanism in this process.The findings indicate the USP2-PPAR-gamma axis has potential as a therapeutic target for metabolic disorders and sarcopenia."
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"Correspondingly, infection with an adenovirus encoding Usp2 shRNA significantly lowered blood glucose, blood insulin, hepatic glycogen content, and insulin sensitivity in high fat diet–fed mice, suggesting that USP2 plays a role in aggravating T2DM pathogenesis [102]."
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"USP2 modulates glucose and lipid metabolism, insulin sensitivity, and inflammatory processes."
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