IndraLab

Statements

USP22 activates apoptotic process. 10 / 12
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"Both elevated exosomal miR-let-7a or silenced USP22 reduced the apoptosis of renal cells and improved kidney function."
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"USP22 depletion could significantly inhibit the proliferation and invasion, and promote the apoptosis of ATC cells in vitro."
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"Further analysis demonstrated that USP22 downregulation activated mitochondrial apoptosis by regulating several apoptosis related proteins, including Bcl-2, Bax, cytochrome c and caspase-3."
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"To investigate the molecular mechanism underlying USP22 silencing induced ATC cell apoptosis, we examined the cellular levels of documented apoptosis regulators or executioners."
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"Additionally, investigation into the underlying mechanism, using small interfering RNA, revealed that the downregulation of USP22 inhibited proliferation and promoted apoptosis though the phosphoinositide 3-kinase/protein kinase B signaling pathway."
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"Silencing of USP22 in podocytes attenuated high d-glucose-induced apoptosis and inflammatory responses, evidenced by increases in proliferation and MMP levels and decreases in the apoptotic rate, ROS production, the Bax and Bcl -2 ratio, caspase-3 expression and secretion of TNF-alpha, IL-1beta, IL-6 and TGF-beta1."
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"Moreover, USP22 down-regulation in HUVECs led to decreased proliferation, angiogenesis, vasodilation, apoptosis, and systolic function."
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"Down-regulation of USP22 expression by siRNA induces the mitochondrial apoptosis of HCC cells."
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"These findings suggest that USP22 accelerates gastric cancer cell proliferation, possibly by suppressing cell apoptosis and promoting the G2/M transition."
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"Our study also shows that USP22 silencing in GC cells decreases cell proliferation and induces cell cycle arrest and apoptosis in vitro, and suppresses tumor growth and metastasis in vivo."
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