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USP22 activates apoptotic process. 23 / 25
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"In further functional analysis, ADAM9 deletion abolished USP22-triggered suppression in proliferation ( Fig. 5 B–D), promotion in apoptosis ( Fig. 5 E), and weakness in invasion and migration abilitie[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Both elevated exosomal miR-let-7a or silenced USP22 reduced the apoptosis of renal cells and improved kidney function."
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"Down-regulation of USP22 expression by siRNA induces the mitochondrial apoptosis of HCC cells."
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"These results suggested that the lack of USP22 could induce apoptosis in Ang II-treated cells and that FO treatment could protect against this reaction."
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"We found that downregulation of USP22 could inhibit Sao-2 cell proliferation, migration, invasion, and induce apoptosis."
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"Therefore, like USP7, accumulating evidence indicates that USP22 also represents a promising target for cancer therapy, and USP22 knockdown markedly decreases cancer growth, induces apoptosis, and sensitizes cancer cells to chemo-radio and immune therapies [17, 34–36]."
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"Downregulation of USP22 induces apoptosis in Sao-2 cells."
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"Additionally, investigation into the underlying mechanism, using small interfering RNA, revealed that the downregulation of USP22 inhibited proliferation and promoted apoptosis though the phosphoinositide 3-kinase/protein kinase B signaling pathway."
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"Under the treatment of Lenvatinib, USP22 knockdown inhibited the cell viability of drug-resistant HCC cells and promoted the apoptosis of drug-resistant cells."
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"Moreover, Usp22 silencing also suppressed renal cell apoptosis, decreased B-cell/CLL lymphoma 2 (Bcl-2)-associated X protein (Bax) mRNA, and concomitantly increased Bcl-2 [137]."
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"Our study also shows that USP22 silencing in GC cells decreases cell proliferation and induces cell cycle arrest and apoptosis in vitro, and suppresses tumor growth and metastasis in vivo."
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"In addition, USP22 was previously shown to modulate apoptosis in various cellular pathways to influence gene expression and protein transduction [42]."
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"USP22 depletion could significantly inhibit the proliferation and invasion, and promote the apoptosis of ATC cells in vitro."
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"Further analysis demonstrated that USP22 downregulation activated mitochondrial apoptosis by regulating several apoptosis related proteins, including Bcl-2, Bax, cytochrome c and caspase-3."
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"Meanwhile, Zhao et al. (15) showed that USP22 silencing restrained cell migration and invasion by inhibiting epithelial-mesenchymal transition in in vitro assays; knockdown of USP22 promoted mitochondrion-mediated and caspase-dependent apoptosis via the upregulation of Bax and Bid and the promotion of caspase-3 activation."
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"In addition, the influence on GSCs growth and apoptosis induced by USP22 exhaustion were attenuated by BMI1 upregulation ( Fig. 2 C–G, P < 0.01)."
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"To investigate the molecular mechanism underlying USP22 silencing induced ATC cell apoptosis, we examined the cellular levels of documented apoptosis regulators or executioners."
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"Silencing of USP22 in podocytes attenuated high d-glucose-induced apoptosis and inflammatory responses, evidenced by increases in proliferation and MMP levels and decreases in the apoptotic rate, ROS production, the Bax and Bcl -2 ratio, caspase-3 expression and secretion of TNF-alpha, IL-1beta, IL-6 and TGF-beta1."
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"Increased USP22 expression may aid in the development of cancer by preventing apoptosis in cancer cells."
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"In fact, suppression of p53 expression largely inhibited the cell apoptosis caused by usp22 deficency ( Figure 6 G), further supporting our conclusion that USP22 regulates cell apoptosis through p53.T[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP22 contributes to the inflammatory response and apoptosis in podocytes through oxidative stress and secretion of inflammatory mediators, up-regulation of caspase-3, and an increase in the BAX/Bcl-2 ratio96."
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"These findings suggest that USP22 accelerates gastric cancer cell proliferation, possibly by suppressing cell apoptosis and promoting the G2/M transition."
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"Functionally, USP22 up-regulation suppressed the viability ( Fig. 4 A) and DNA synthesis activity ( Fig. 4 B) and induced apoptosis ( Fig. 4 C) in JEG-3 and HTR-8/SVneo cells."
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