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ANK3 activates CACNA1C. 2 / 2
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"Similarly, the well documented functions of ankyrin G in localizing inhibitory GABAergic interneuron synapses to the AIS of excitatory neurons, as well as mediating activity dependent AIS relocation along axons, further supports a common mechanism of ANK3 and CACNA1C in regulation of neuronal excitability."
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"We report support for two of the three most strongly associated chromosomal regions in the Ferreira study, CACNA1C (rs1006737, P = 4.09 x 10 (-4)) and 15q14 (rs2172835, P = 0.043) but not ANK3 (rs10994336, P = 0.912)."
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