IndraLab

Statements

COPS6 activates E3_Ub_ligase. 3 / 3
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"For example, CSN6, a component of the COP9 signalosome, positively regulate E3 ubiquitin ligases."
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"It has been reported that CSN6 can promote some degree of tumor progression by regulating the stability of several E3 ligases XREF_BIBR - XREF_BIBR, XREF_BIBR."
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"Mechanistic studies show that CSN6 binds and regulates FOXO4 stability through enhancing the E3 ligase activity of COP1, and that COP1 directly interacts with FOXO4 through a VP motif on FOXO4 and accelerates the ubiquitin-mediated degradation of FOXO4."
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