IndraLab

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USP15 binds E6. 13 / 13
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"As TRIM25 protein stability is regulated by the balance between degradative K48 linked ubiquitination and USP15 mediated deubiquitination, the authors performed coimmunoprecipitation experiments in HEK 293T and cervical-carcinoma-derived C33a cells ectopically expressing FLAG tagged E6 of HPV16, showing that E6 binds exogenous TRIM25 and USP15, giving rise to a ternary E6, TRIM25, and USP15 complex."
32316236
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [ xref ]."
33922750
sparser
"This study focuses on the functional consequences of the interaction of E6 with USP15."
19553310
sparser
"In addition, a recent study has found that the interaction between USP15 and E6 contributes to viral immune evasion by suppressing RIG-I-mediated immune activation ( xref ), suggesting a complex relationship between the viral oncoprotein and host factors."
31749782
virhostnet
No evidence text available
28786561
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45]."
33922750
virhostnet
No evidence text available
28786561
sparser
"The ubiquitin-specific peptidase USP15, a member of the largest subfamily of deubiquitinating enzymes (DUBs), binds to HPV E6 and regulates E6 protein stability ( xref ; xref )."
31749782
sparser
"In addition, putative mechanisms modulating E6-mediated degradation have been proposed, which include proteasome-mediated degradation of both E6 ( xref ) and E6AP ( xref ), stabilization of E6 by E6AP ( xref ), E6 interaction with the deubiquitinating enzyme USP15 ( xref ) and inhibition of the E6/E6AP activity by the EDD ubiquitin ligase ( xref )."
22483108
reach
"In addition, putative mechanisms modulating E6 mediated degradation have been proposed, which include proteasome mediated degradation of both E6 and E6AP, stabilization of E6 by E6AP, E6 interaction with the deubiquitinating enzyme USP15 and inhibition of the E6/E6AP activity by the EDD ubiquitin ligase."
22483108
reach
"HPV E6 binds to both TRIM25 and USP15 when ectopically expressed or in natively HPV infected cells."
33530371
reach
"Here, we show that the E6 oncoprotein of human papillomavirus type 16 (HPV16) as well as of other HPV types form a complex with TRIM25 and USP15 in human cells."
29263274
sparser
"This study did not identify any effects of the E6-USP15 interaction on p53 signaling pathway [ xref ]."
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