IndraLab

Statements

ABRAXAS1 activates BRCC3. 3 / 3
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"The key compositional differences between the two complexes are the two scaffolding partners of BRCC36 (Figure S1A): in BRCA1-A, BRCC36 is supported by ABRAXAS (Wang et al., 2007), whereas in BRISC, it is paired with ABRO1 (Hu et al., 2011a, Wang et al., 2007)."
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"Abraxas brother 1 (ABRO1), a subunit of the BRCA1/BRCA2-containing complex subunit 36 (BRCC36) isopeptidase complex (BRISC), impedes WW domain-containing E3 ubiquitin-protein ligase 2 (WWP2)-mediated BRCC3 ubiquitination and increases BRCC3 stability [69]."
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"BRCC36 is activated in the BRCA1-A complex by the MPN domain protein ABRAXAS and in BRISC particles by the MPN domain protein ABRO1 (Rabl, 2020)."
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