IndraLab

Statements

3',5'-cyclic AMP activates KCNMA1. 9 / 9
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"CAMP dependent mediation of MaxiK channel in the relaxant response to isoprenaline was evidenced since the potentiated response to isoprenaline by the presence of Ro-20-1724 (1 microM) was inhibited by the channel selective blocker, iberiotoxin (IbTx, 100 nM)."
15048013
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"Although the molecular identities of BK splice variants of rat and human colon have yet to be established, the demonstration that cAMP activates BK channel activity, and forskolin (FSK; which activates adenylate cyclase and increases intracellular cAMP) activates K secretion, suggest that BK channels encoded by ZERO transcripts mediate K secretion in rat and human colonic epithelial cells (Figure-7) (130, 159)."
30215859
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"The fact that the wider cryptal distribution of BK channel expression persists in quiescent UC (where colonic K secretion is likely to be normal), suggests that fecal K losses in UC are also dependent upon overall BK channel activity, which is likely to be stimulated in active UC by cAMP and/or Ca -mediated inflammatory cytokines."
30215859
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"Thus, cAMP elevation with the subsequent activation of A-kinase may mediate the activation of MaxiK channels, leading to the relaxant response of mesenteric artery to VIP."
10594322
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"BK channel activation by cAMP in rat colonocytes."
19407217
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"These results suggested that the relaxing mechanism of papaverine in the bovine trachea is mainly due to increases of cAMP content by inhibiting phosphodiesterase and the mechanism is partially involved in the activation of BK channel by cAMP."
15988126
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"The directed focus therefore covers the role of the apical Ca2+ and cAMP activated BK channel (KCa1.1) as the apparently only secretory K+ channel in the distal colon."
20143237
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"Although we did not study the effects of specific BK channel inhibitors in this study, we have previously shown that apically applied 100 nM iberiotoxin completely inhibits cAMP induced K + secretion in rat distal colon by preventing the apical BK channel mediated increase in unidirectional K + flux from serosa to mucosa, and 100 nM penitrem A inhibits apical BK channels in human colon."
27609768
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"[Molecular mechanisms for cAMP independent activation of MaxiK channel : G protein direct channel regulation and contribution to the tuning of vascular smooth muscle tone]."
14727517