IndraLab

Statements

KCNH2 leads to the phosphorylation of PI3K. 2 / 2
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"In the mesoderm phase of rESCs, the interaction of ERG1 with Integrin beta1 can activate the AKT pathway by recruiting and phosphorylating PI3K p85 and focal adhesion kinase (FAK) to further phosphorylate AKT."
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"In addition to the increase in hERG1 currents, β1 activation leads hERG1 to form a macromolecular membrane complex that comprises the β 1 integrin subunit and the p85 subunit of PI3K. Recruitment of p85 inside the complex has two major consequences: i) it facilitates translocation of PI3K towards its physiological membrane substrates; ii) it determines a hERG1-dependent PI3K phosphorylation, without the need of intermediate cytosolic proteins (e.g. FAK, ILK, Src)."
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