IndraLab

Statements

Sertraline inhibits KCNA5. 12 / 12
| 12
sparser
"The voltage-dependent inhibition of Kv1.5 by sertraline implies that the inhibition of Kv1.5 by sertraline occurs preferentially after the channels are open [ xref xref xref xref xref xref xref ]."
26937216
sparser
"The result of voltage-dependent inhibition of Kv1.5 by sertraline shows an additional low degree of inhibition detected in the voltage range positive to +10 mV despite Kv1.5 being fully activated at this voltage range ( xref )."
26937216
sparser
"To further investigate the time-dependent inhibition of Kv1.5 by sertraline, deactivation kinetics of Kv1.5 current was studied. xref shows the representative superimposed tail currents recorded with a 250-ms repolarizing pulse at –40 mV after a 250-ms depolarizing pulse of +50 mV from a holding potential of –80 mV, under control conditions and in the presence of 1 µM sertraline."
26937216
sparser
"In this study, the characteristics of the sertraline-induced inhibition of Kv1.5 suggest that sertraline preferentially interacts with the open state of Kv1.5 based on the following lines of evidence."
26937216
sparser
"Use- and frequency-dependent inhibition of Kv1.5 by sertraline."
26937216
sparser
"Inhibition of Kv1.5 by sertraline was use-dependent."
26937216
sparser
"For an analysis of a frequency-dependent inhibition of Kv1.5 by sertraline without contamination of the decline of the current under control conditions, the relative currents (I Sertraline /I Control ) at 1 and 2 Hz were plotted ( xref )."
26937216
sparser
"The phospholipid composition of the cell may be different from human native cardiac myocytes and the differences of membrane composition may affect sertraline-induced Kv1.5 inhibition."
26937216
sparser
"3) The inhibition of Kv1.5 induced by sertraline was highly voltage-dependent and increased steeply in the voltage range of channel activation."
26937216
sparser
"Time-dependent inhibition of Kv1.5 by sertraline."
26937216
sparser
"Concentration-dependent and reversible inhibition of Kv1.5 by sertraline."
26937216
sparser
"Voltage-dependent inhibition of Kv1.5 by sertraline."
26937216