IndraLab

Statements

Sertraline inhibits KCNA5. 12 / 12
| 12
sparser
"Concentration-dependent and reversible inhibition of Kv1.5 by sertraline."
26937216
sparser
"Voltage-dependent inhibition of Kv1.5 by sertraline."
26937216
sparser
"Time-dependent inhibition of Kv1.5 by sertraline."
26937216
sparser
"To further investigate the time-dependent inhibition of Kv1.5 by sertraline, deactivation kinetics of Kv1.5 current was studied. xref shows the representative superimposed tail currents recorded with a 250-ms repolarizing pulse at –40 mV after a 250-ms depolarizing pulse of +50 mV from a holding potential of –80 mV, under control conditions and in the presence of 1 µM sertraline."
26937216
sparser
"Use- and frequency-dependent inhibition of Kv1.5 by sertraline."
26937216
sparser
"For an analysis of a frequency-dependent inhibition of Kv1.5 by sertraline without contamination of the decline of the current under control conditions, the relative currents (I Sertraline /I Control ) at 1 and 2 Hz were plotted ( xref )."
26937216
sparser
"In this study, the characteristics of the sertraline-induced inhibition of Kv1.5 suggest that sertraline preferentially interacts with the open state of Kv1.5 based on the following lines of evidence."
26937216
sparser
"3) The inhibition of Kv1.5 induced by sertraline was highly voltage-dependent and increased steeply in the voltage range of channel activation."
26937216
sparser
"The voltage-dependent inhibition of Kv1.5 by sertraline implies that the inhibition of Kv1.5 by sertraline occurs preferentially after the channels are open [ xref xref xref xref xref xref xref ]."
26937216
sparser
"The result of voltage-dependent inhibition of Kv1.5 by sertraline shows an additional low degree of inhibition detected in the voltage range positive to +10 mV despite Kv1.5 being fully activated at this voltage range ( xref )."
26937216
sparser
"The phospholipid composition of the cell may be different from human native cardiac myocytes and the differences of membrane composition may affect sertraline-induced Kv1.5 inhibition."
26937216
sparser
"Inhibition of Kv1.5 by sertraline was use-dependent."
26937216