IndraLab

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USP10 inhibits cell population proliferation. 29 / 29
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"16 Our previous studies have shown that USP10 inhibits mTOR activation and suppresses the proliferation of HCC."
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"USP10 inhibits NSCLC cell viability, proliferation, and migration."
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"Inhibition of USP10 may induce lysosomal ribosome degradation and thereby control cell proliferation or metabolism."
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"Furthermore, USP10 inhibits tumor cell proliferation by increasing p53 levels in cells with wild‐type p53, but exacerbates tumorigenesis in tumor cells with mutant p53 background."
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"Furthermore, we provide evidence that USP10 inhibits cancer cell proliferation in cells with WT p53."
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"Because EdU incorporation is a biomarker for thymidine uptake in DNA synthesis and cell proliferation, this result firmly supported that USP10 suppresses NSCLC proliferation by inhibiting DNA synthesis."
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"All in all, these results demonstrated that USP10 is downregulated in NSCLC cells, and restoration of USP10 inhibits NSCLC cell proliferation and migration by targeting the PTEN/AKT/mTOR pathway via preventing PTEN from K63-linked polyubiquitination."
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"On the other hand, reconstitution of USP10 in cells with USP10 downregulation inhibited cancer cell proliferation (XREF_FIG), suggesting the effect of USP10 knockdown is specific."
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"Current studies have also shown that USP10 suppressed proliferation and growth of pancreatic cancer cells."
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"Loss of USP10 promotes hepatocellular carcinoma proliferation by regulating the serine synthesis pathway through inhibition of LKB1 activity."
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"Collectively, these results show that downregulation of USP10 can inhibit the proliferation and metastasis of OS cells in vivo.3.8 USP10 stabilizes the expression of YAP1 by mediating its deubiquitination in OS cells."
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"We showed that loss or inhibition of USP10 not only suppressed the proliferation of imatinib sensitive and imatinib resistant cells in vitro but also inhibited the growth of imatinib sensitive and imatinib resistant xenografts in vivo."
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"A particularly important observation was that knockdown of USP10 in wild-type p53 cell lines promoted proliferation and metastasis, suggesting that USP10 could inhibited tumor development under the background of wild-type p53."
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"He et al., also illustrated that USP10 inhibits non-small cell lung cancer cell proliferation by restoring PTEN activity (He et al. 2021)."
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"In contrast, overexpressing USP10 expression in MHCC97L and BEL-7402 cells reduced the cell proliferation."
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"HBX19818 and P22077, inhibitors of USP10, promote the degradation of FLT3-ITD and inhibit the proliferation of AML cells in vitro ( Table 2 )."
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"The research by Yuan et al. demonstrated that USP10 inhibits cancer cell proliferation in wild-type p53 cells, but promotes tumorigenesis in a mutant p53 background (Yuan et al., 2010)."
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"As expected, USP10 over expression inhibited the proliferation of colon cancer cells with either a wildtype p53 or with p53-deficency."
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"Through the LKB1/mTOR/activating transcription factor 4 (ATF4) axis, loss of USP10 may increase serine biosynthesis and promote the proliferation of HCC in vitro and in vivo."
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"This body of evidence indicated that USP10 knockdown can limit proliferation and dissemination of PAAD cells in vitro.3.5 Knockdown of USP10 reduces pancreatic adenocarcinoma tumorigenesis in mice."
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"The deubiquitinase USP10 restores PTEN activity and inhibits non-small cell lung cancer cell proliferation."
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"Furthermore, the double knock-down of G3BP1 and USP10 rescued the inhibition of proliferation induced by G3BP1 depletion in HCT116 (XREF_FIG) and SK-MEL-5 cells (XREF_SUPPLEMENTARY)."
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"Here, we show that USP10 knockout significantly increased proliferation in HCT116 cells, which was observed already after 48 h by a cell counting assay (Supplementary Figure S3)."
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"Furthermore, we provide evidence that USP10 inhibits cancer cell proliferation in cells with WT p53."
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"Consistent with its molecular activity, re-expression of USP10 suppressed NSCLC cell proliferation and migration, whereas knockout of USP10 promoted NSCLC cell proliferation and migration."
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"However, this study has shown that the changes in proliferation caused by USP10 knockout in HCT116 are not conducted via HIF-1α."
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"Conversely, downregulation of USP10 inhibited cell proliferation ( xref and data not shown)."
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"Conversely, downregulation of USP10 inhibited cell proliferation (XREF_FIG and data not shown)."
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"The reconstitution of USP10 inhibited the colony formation and cell proliferation of the CAKI-1 and CAKI-2 RCC cell lines."
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