IndraLab

Statements

EIF3F binds 9G8. 6 / 6
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"We show that eIF3f specifically interacts with 9G8 and CDK11 and together they alter the 3 ' end processing of the HIV-1 pre-mRNA in a sequence specific manner."
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"Furthermore, we observed that FLAG tagged 9G8 specifically interacts with endogenous eIF3f and myc tagged eIF3f (XREF_FIG, lanes 2 and 5)."
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"Together these results show that CDK11 and 9G8 both interact with eIF3f."
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"We confirmed that eIF3f interacts with CDK11 and showed that there is a specific interaction between eIF3f and 9G8 in vivo."
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"These data suggest that the proper interaction of eIF3f, CDK11 and 9G8 is required for efficient HIV-1 pre-mRNA processing and viral gene expression."
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"To test whether a previously undescribed interaction between eIF3f and 9G8 exists and to confirm the previously reported interaction between CDK11 and eIF3f in our cell line, TE671, we performed co-immunoprecipitation experiments."
19854136