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COPS6 decreases the amount of UBR5. 2 / 2

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"Furthermore, we found that UBR5 knockdown rescued all the effects induced by CSN6 silencing, indicating that CSN6 activates the CDK9 pathway to promote melanoma growth and metastasis by reducing the UBR5 level."

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"Next, western blot analysis demonstrated that CSN6 increased CDK9 expression and decreased UBR5 expression in a dose dependent manner in 293FT cells."

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IndraLab

Statements

COPS6 decreases the amount of UBR5. 2 / 2

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