IndraLab

Statements

USP4 binds HUWE1. 9 / 15
4 | 7 2
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"USP4 interacts directly with and deubiquitinates ADP-ribosylatibon factor binding protein 1 (ARFBP1), which results in the stabilization of ARF-BP1 and the subsequent reduction of p53 levels."
27430936
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"USP4 negatively regulates p53 by binding to ARF-BP1 and deubiquitinates it thereby promoting ARF-BP1-dependent ubiquitination and degradation of p53."
29479529
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"USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels."
21522127
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"For example, USP4 interacts directly with and deubiquitinates ARF binding protein 1 (ARF-BP1), leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels."
26411366
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"USP4 interacts directly with and deubiquitinates ADP-ribosylatibon factor-binding protein 1 (ARF-BP1), leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels [12] ."
23313255
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"Furthermore, USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels [XREF_BIBR]."
25972356
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"This regulation depends on the binding of USP4 to ARF-BP1 through deubiquitination, promoting ARF-BP1-dependent ubiquitination and degradation of p53, which indicates its tumor-promoting role [ xref ]."
35884430
sparser
"In human osteosarcoma cells, USP4 can directly bind to and deubiquitinate ARF-BP1, which stabilises ARF-BP1 and reduces p53 levels, thereby promoting cancer cell proliferation ( xref )."
36969062
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"USP4 also interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels."
28791349