IndraLab

Statements


USP22 increases the amount of BMI1. 6 / 6
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"Above, we demonstrated that USP22 silencing predominantly decreases the BMI1 protein levels rather than mRNA expression, and further alters GC cell proliferation, gastric CSC formation and maintenance of stem cell stemness, indicating post-transcriptional regulation of BMI1."

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"Our results showed that USP22 silencing significantly down-regulated BMI1 protein expression and further affected gastric CSC self-renewal."

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"We found USP22 silencing led to decreased expression of BMI1, as well as decreased P21 levels."

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"We have reported that USP22 mediates cell survival and proliferation by promoting the expression of BMI-1 and upregulation of activated AKT pathway in colon cancer cells."

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"USP22 knockdown remarkably decreased BMI1 protein level, but it barely affected BMI1 mRNA level in glioma cell lines."

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"USP22 knockdown inhibits glioma stemness partially by downregulating the protein level but not the transcriptional level of BMI1."