IndraLab

Statements

UCHL5 deubiquitinates TGFBR1. 7 / 8
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"Ultimately, UCH37 deubiquitinates the activated ALK5 and rescues it from proteasomal degradation [ 22 , 23 ]."
37406898
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"XREF_BIBR reported that UCHL5 de-ubiquitinates and stabilizes TbetaRI in human cancer cells."
27604640
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"ADRM1–UCH37 interaction not only activated UCH37 activity but was also important for UCH37 stability.Previous literature has reported that ADRM1 could bind to UCH37 and activate its deubiquitination a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37406898
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"Similarly to USP15, another deubiquitylating enzyme, UCH37, forms a complex with Smad7 by binding to a sequence that is distinct from the PY motif with which Smurf1 or Smurf2 interact, and also deubiquitylates and stabilizes TbetaRI."
22617150
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"It has been revealed that the DUBs, UCH37, USP11, and USP15, de-ubiquitinate and stabilize TbetaRI."
27853171
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"One such DUB is UCH37, which was shown to bind to Smad7 and deubiquitinate TbetaRI."
22335355
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"Studies have provided evidence that ALK5 could mediate the activation of Smad2/3, thus preventing chondrocyte hypertrophy and stimulating COL2a1 and proteoglycan synthesis [ 20 , 21 ], which means tha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37406898