IndraLab

Statements

UCHL5 deubiquitinates TGFBR1. 5 / 5
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"XREF_BIBR reported that UCHL5 de-ubiquitinates and stabilizes TbetaRI in human cancer cells."
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"One such DUB is UCH37, which was shown to bind to Smad7 and deubiquitinate TbetaRI."
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"Via SMAD7, UCH37 can further be recruited to TβRI, where it removes polyubiquitin chains synthesized by SMURF"
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"It has been revealed that the DUBs, UCH37, USP11, and USP15, de-ubiquitinate and stabilize TbetaRI."
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"Similarly to USP15, another deubiquitylating enzyme, UCH37, forms a complex with Smad7 by binding to a sequence that is distinct from the PY motif with which Smurf1 or Smurf2 interact, and also deubiquitylates and stabilizes TbetaRI."
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