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Statements

TRPV2 binds TRPV4. 12 / 12
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"We have preliminary evidence that TRPV4 and TRPV2 are associated in kidney cortical collecting duct cells (data not shown), suggesting that TRP regulation of blood-brain barrier function RC Brown et al. 369 the endogenous channels in BBB endothelial cells could consist of both isoforms."
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"These data demonstrate that each of the MSCs has a unique distribution pattern, and their proportion varies among the neurons and cellular compartments with the rod OS disks, rod OS membrane, cone OS, OPL, and the axon terminals of photoreceptors, IPL, and GCL expressing TRPV2, TRAAK, TRPV2-TRAAK, TRPV2-TRPV4-TRAAK, and TRPV2-TRPV4, respectively."
34067375
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"Kaplan-Meier survival curve analysis found that TRPV2 and TRPV4 were significantly associated with HCC patients at stage ii&iii and stage iii&iv, but not at stage all and stage i and ii (Supplementary Fig. xref )."
37369706
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"Other proteins that could be related to the Arf1 pathway, identified as TRPV2 and TRPV4 interactions, are Arl15 (Arf-like protein) and the CALM/CamK2B/Cask subset, respectively ( xref and xref )."
31783610
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"TRPV1, like the related TRPV2–TRPV4 channels and other transient receptor potential (TRP) channels, features a pore that is non-selective for cations and exhibits significant permeability to Ca 2+ [ xref ]."
39273976
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"However, we cannot totally exclude the possibility that TRPV2 and TRPV4 form a heterodimer and translocate to the site receiving mechanical stress."
25677550
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"The interaction of TRPV2 and TRPV4 with lipids and/or with lipid modifying enzymes points to the fact that the lipid environment is fundamental for TRPV2 and TRPV4 trafficking, beyond the TRPV2 and TRPV4 lipid requirement for ion channel function."
31783610
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"In the same family, TRPV2 has been described in hDCs, and seems to be involved in the management of heat-shock protein response at high temperatures, probably associated in TRPV2–TRPV1 and TRPV2–TRPV4[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29574094
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"However, we can not totally exclude the possibility that TRPV2 and TRPV4 form a heterodimer and translocate to the site receiving mechanical stress."
25677550
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"As seen in Supplementary Fig. 2 , both TRPV1 and TRPV4 antibodies detected immunosignals in the TRPV2-precipitate which findings suggest that TRPV2-TRPV1 and TRPV2-TRPV4 heteromerization may take plac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23542034
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"BBB permeability is increased by activation of TRPV4 and TRPV2 complex."
25914628
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"Evidence that TRPV channels may be involved in the remodeling of the actin cytoskeleton comes from studies in dorsal root ganglion and epithelial cells, which have demonstrated the binding of TRPV2 and TRPV4 channels to proteins involved in maintaining barrier function, such as β-catenin/N-cadherin complex, actin, and tubulin at their C-terminus. xref , xref Further, the localization of TRPV1 and TRPV4 at the focal adhesions xref , xref indicate that these channels may be involved in maintaining the intercellular barrier, regulating cell migration, and cell adhesion to the substrate."
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