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IL1B increases the amount of CD44. 26 / 31
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"Therefore, it is very likely that CD44 is related to hyaluronic acid production in human uterine cervix.Our study is the first report that IL-1beta increases the expression of CD44 mRNA in cultured hu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"IL-1beta, at concentrations from 1 to 100 pg/ml, stimulated CD44 mRNA expression in a dose dependent manner."
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"CD44 expression is induced by IL-1beta in inflammatory diseases such as arteriosclerosis."
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"IL-1beta furthermore upregulated the expression of the integrin subunits alpha1, alpha2 and the adhesion molecule CD44 while the latter was downregulated by TNF-alpha."
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"We also knocked down IL-1beta in + DLX4 ES2 cells to a level comparable to that of vector-control ES2 cells (Supplemental Figure S4 B) and observed that knockdown of IL-1beta reduced CD44 expression a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Reconstitution of IL-1beta in DLX4-knockdown 2008 cells restored CD44 expression and mesothelial attachment ability to levels comparable to those of control 2008 cells (Supplemental Figure S5, C and D[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Northern analysis showed that IL-1beta promoted a dose- and time dependent induction of CD44 mRNA which reached 6.6-fold after 48 h, and nuclear run-on analysis showed that IL-1beta increased the rate of CD44 gene transcription within 8 h of stimulation."
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"Regulation of CD44 gene expression by the proinflammatory cytokine IL-1beta may contribute to SMC phenotypic modulation in the pathogenesis of arteriosclerosis."
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"Liang et al. [23] found that TNFa and IL1B promoted adhesion between gastric cancer cells and peritoneal mesothelial cells by increasing the levels of ICAM1, VCAM1 and CD44 mRNAs, which play a positive role in the peritoneal implantation and metastasis of gastric cancer cells.KEGG enrichment analysis showed that the target genes may be involved in gastric cancer through effects on the MAPK signaling pathway, proteoglycan in cancer, EGFR tyrosine kinase inhibitor resistance, and other biological pathways."
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"-Foster, L. C., Wiesel, P., Huggins, G. S, Panares, R., Chin, M. T., Pellacani, A., Perrella, M. A. Role of activating protein-1 and high mobility group-I (Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells."
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"In contrast, free HMW HA and CA had no effects on IL-1β-induced expression of Cd44 , Mmp3 , Mmp13 , and Cox2 in chondrocytes ( Supplementary Fig. 9 )."
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"IL-1beta increases inflammatory markers and CD44 expression in NP cells."
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"It is possible that the elevated IL-1β levels could then stimulate CD44 expression and shedding in ECs in an autocrine manner.The co-localization of CD44H and its variants CD44v3, CD44v6, and CD44v7/8[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Because sCD44 can induce IL-1β expression in ECs, this released IL-1β, together with IL-1β expressed by other surrounding vascular cells, might act in an autocrine manner to stimulate CD44 expression [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Role of activating protein-1 and high mobility group-I (Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells."
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"Vitexin also reduced the levels of the pyroptosis related proteins GSDMD, NLRP3, cleaved caspase-1, and mature IL-1beta, which were elevated in mice with nephrolithiasis, and repressed apoptosis and the expression of OPN and CD44."
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"These data suggest that all CD44 variant expression transcription is supressed by TGF-β1 and promoted by IL-1β."
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"Conversely, the proinflammatory cytokine IL-1β increased the expression of all identified CD44 variants."
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"Regulation of CD44 gene expression by the proinflammatory cytokine interleukin-1beta in vascular smooth muscle cells."
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"IL-1β also can induce the expression of MET proto-oncogene, CD44 , urokinase receptor , matrix metalloproteinases ( MMPs ), C-X-C motif chemokine ligand 8 ( CXCL8 ), and vascular endothelial growth fa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"TG2 overexpression in MCF7 cells increased the surface expression of breast cancer stem cell marker CD44, and IL-1beta stimulation of MCF7_TG2 breast cancer cells further increased CD44 expression (Additional file 1 : Figure S3)."
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"The addition of a specific CD44 blocking antibody (CD44-Ab) abolished increased CD44 expression induced by IL-1β stimulation and by IL-1β plus HYAL."
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"Interestingly, IL-1β has been shown to increase levels of CD44 while TNF-α causes an opposite effect [52]."
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"Exogenous IL-1β caused a dose- and time-dependent induction of CD44 expression in rat aortic smooth muscle cells and increased the rate of CD44 gene transcription within 8 h of stimulation [105]."
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"However, in osteoarthritis, activation of TLR2 and TLR4 induce IL-1β and TNF-α release that notably increased CD44 gene expression and protein concentrations in human macrophages, whereas blocking CD44 with anti-CD44 Ab or HA show opposite results [116]."
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"IL-1beta, at concentrations from 1 to 100 pg/ml, stimulated the expression of CD44 mRNA in a dose dependent manner."
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