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IL1B increases the amount of CD44. 21 / 26
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"IL-1beta, at concentrations from 1 to 100 pg/ml, stimulated the expression of CD44 mRNA in a dose dependent manner."
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"Vitexin also reduced the levels of the pyroptosis related proteins GSDMD, NLRP3, cleaved caspase-1, and mature IL-1beta, which were elevated in mice with nephrolithiasis, and repressed apoptosis and the expression of OPN and CD44."
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"Exogenous IL-1β caused a dose- and time-dependent induction of CD44 expression in rat aortic smooth muscle cells and increased the rate of CD44 gene transcription within 8 h of stimulation [105]."
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"TG2 overexpression in MCF7 cells increased the surface expression of breast cancer stem cell marker CD44, and IL-1beta stimulation of MCF7_TG2 breast cancer cells further increased CD44 expression (Additional file 1 : Figure S3)."
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"We also knocked down IL-1beta in + DLX4 ES2 cells to a level comparable to that of vector-control ES2 cells (Supplemental Figure S4 B) and observed that knockdown of IL-1beta reduced CD44 expression a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"IL-1beta, at concentrations from 1 to 100 pg/ml, stimulated CD44 mRNA expression in a dose dependent manner."
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"It is concluded from the present study that human cervical CD44 mRNA expression is induced by interleukin-1beta."
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"However, in osteoarthritis, activation of TLR2 and TLR4 induce IL-1β and TNF-α release that notably increased CD44 gene expression and protein concentrations in human macrophages, whereas blocking CD44 with anti-CD44 Ab or HA show opposite results [116]."
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"Role of activating protein-1 and high mobility group-I (Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells."
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"IL-1beta furthermore upregulated the expression of the integrin subunits alpha1, alpha2 and the adhesion molecule CD44 while the latter was downregulated by TNF-alpha."
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"Conversely, the proinflammatory cytokine IL-1β increased the expression of all identified CD44 variants."
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"Regulation of CD44 gene expression by the proinflammatory cytokine IL-1beta may contribute to SMC phenotypic modulation in the pathogenesis of arteriosclerosis."
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"Interleukin-1beta stimulated the expression of CD44 mRNA in a dose dependent manner."
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"Therefore, it is very likely that CD44 is related to hyaluronic acid production in human uterine cervix.Our study is the first report that IL-1beta increases the expression of CD44 mRNA in cultured hu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Expression of CD44 mRNA induced by interleukin-1beta in human cultured uterine cervical fibroblasts."
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"Northern analysis showed that IL-1beta promoted a dose- and time dependent induction of CD44 mRNA which reached 6.6-fold after 48 h, and nuclear run-on analysis showed that IL-1beta increased the rate of CD44 gene transcription within 8 h of stimulation."
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"Regulation of CD44 gene expression by the proinflammatory cytokine interleukin-1beta in vascular smooth muscle cells."
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"CD44 expression is induced by IL-1beta in inflammatory diseases such as arteriosclerosis."
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"These data suggest that all CD44 variant expression transcription is supressed by TGF-β1 and promoted by IL-1β."
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"Reconstitution of IL-1beta in DLX4-knockdown 2008 cells restored CD44 expression and mesothelial attachment ability to levels comparable to those of control 2008 cells (Supplemental Figure S5, C and D[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"-Foster, L. C., Wiesel, P., Huggins, G. S, Panares, R., Chin, M. T., Pellacani, A., Perrella, M. A. Role of activating protein-1 and high mobility group-I (Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells."
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