IndraLab

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USP22 activates Osteosarcoma. 9 / 10
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"In addition, deficiency of ALKBH5‐mediated m6A modification in osteosarcoma causes an increase expression of histone deubiquitinase USP22 and ubiquitin ligase RNF40, which inhibits histone H2AK199 monoubiquitination, induces the expression of genes related to DNA repair, and promotes the progression of osteosarcoma."
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"In addition, the expression of USP22 promotes the proliferation of osteosarcoma cells in a glycolytic dependent manner both in vitro and in vivo, while the knockout of USP22 is the opposite."
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"We also confirmed that USP22 enhanced viability and motility of osteosarcoma cells."
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"The detailed mechanism of USP22-mediated osteosarcoma is still elusive.In the present study, we investigated the expression and biological functions of linc00265 in osteosarcoma cells."
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"The molecular mechanisms by which USP22 promotes osteosarcoma involve multiple signaling pathways, including glycolysis, oxidative phosphorylation, Spliceosome, Thermogenesis, and Cell cycle."
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"Significance : RNA demethylase ALKBH5 upregulates USP22 and RNF40 to inhibit histone H2A ubiquitination and induces expression of key replication and DNA repair-associated genes , driving osteosarcoma progression ."
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"Silencing of either USP22 or RNF40 reduced short-term cell viability and clonogenic growth of osteosarcoma cells (Fig. 6A and B)."
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"USP22 Promotes Osteosarcoma Progression by Stabilising β-Catenin and Upregulating HK2 and Glycolysis."
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"CCK-8 data showed that USP22 overexpression accelerated viability of osteosarcoma cells, which was rescued by miR-485-5p upregulation ( Figure 6A )."
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