IndraLab

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OTUB1 inhibits polyubiquitin chains. 4 / 4
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"We demonstrated that OTUB1 attenuates polyubiquitin chains on FGFR2 independent of its enzyme activity."
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"Following that, we investigated which lysine (K)linked polyubiquitin chains of RACK1 might be eliminated by OTUB1."
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"Together, these data suggest that OTUB1 prevents FGFR2 from lysosomal degradation by inhibiting the degradative polyubiquitin chains."
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"In sharp contrast, OTUB1 treatment diminished high-molecular-weight polyubiquitin chains and concomitantly caused the accumulation of short ubiquitin chains, indicating that the K48 linkage decorates [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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