IndraLab

Statements

CTNNB1 bound to CDH1 inhibits CTNNB1. 8 / 8
| 8
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"Hence, a reduced binding affinity between beta-catenin and E-cadherin is expected to increase the signaling pool of beta-catenin, possibly leading to enhanced nuclear signaling."
31857074
reach
"E-cadherin binding to beta-catenin prevents nuclear localization of beta-catenin and beta-catenin and LEF-1-mediated transactivation [XREF_BIBR, XREF_BIBR]."
20459685
reach
"The CagA and E-cadherin interaction impairs the complex formation between E-cadherin and beta-catenin, causing cytoplasmic and nuclear accumulation of beta-catenin."
17237808
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"In the stomach, CagA physically interacts with E-cadherin and impairs the complex formation between E-cadherin and beta-catenin, causing cytoplasmic and nuclear accumulation of beta-catenin."
21984436
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"In CAC, E-cadherin forms a complex with beta-catenin and in combination with the actin cytoskeleton prevents nuclear translocation of beta-catenin, thus regulating the activity of the Wnt and catenin signaling pathways [XREF_BIBR]."
28145888
reach
"However, upon infection with CagA positive H. pylori strains, CagA will become competitive in combination with E-cadherin and disrupt complex formation between E-cadherin and beta-catenin, causing cytoplasmic and nuclear accumulation of beta-catenin."
26160167
reach
"Binding of beta-catenin and E-cadherin at the cell junction is indicative of the antagonism of the Wnt pathway restricting nuclear translocation of beta-catenin XREF_BIBR."
25290150
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"Indeed, disruption of E-cadherin and beta-catenin complexes leads to the loss of epithelial polarization and allows nuclear translocation of beta-catenin."
26025664