IndraLab

Statements

Pentamidine decreases the amount of KCNH2. 4 / 4
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"Taken together, our data imply that chronic administration of pentamidine at clinically relevant exposure reduces the membrane expression of the hERG channel, which may most likely be the major mechanism of QT prolongation and torsade de pointes reported in man."
15711592
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"Pentamidine reduces hERG expression to prolong the QT interval."
15711592
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"In XREF_FIG, pentamidine markedly reduced hERG expression on the membrane, but application of 1, 10, and 30 muM quinidine (A) or quinine (B) did not increase the 155-kDa hERG level in the presence of 30 muM pentamidine."
27690007
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"The present study was designed to provide a more complete picture of how hERG surface expression is disrupted by pentamidine at the cellular and molecular levels."
22046004