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Pentamidine decreases the amount of KCNH2. 12 / 12
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"No change was observed upon 5 min of acute exposure to pentamidine ( Fig. 2 A).17-AAG also decreased the levels of mature hERG protein at 1 and 3 μM for 24 h (13.9% ± 0.9%, P < 0.05%, and 10.3% ± 2.1%[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30391349
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"In addition, upon chronic (10 μM) but not acute (up to 30 μM) exposure, pentamidine decreased the level of mature hERG protein in hERG-CHOs ( Fig. 2 B) and prolonged FPD cB in hES-CMs ( Fig. 5 )."
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"The present study was designed to provide a more complete picture of how hERG surface expression is disrupted by pentamidine at the cellular and molecular levels."
22046004
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"Pentamidine reduces hERG expression to prolong the QT interval."
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"In XREF_FIG, pentamidine markedly reduced hERG expression on the membrane, but application of 1, 10, and 30 muM quinidine (A) or quinine (B) did not increase the 155-kDa hERG level in the presence of 30 muM pentamidine."
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"Taken together, our data imply that chronic administration of pentamidine at clinically relevant exposure reduces the membrane expression of the hERG channel, which may most likely be the major mechanism of QT prolongation and torsade de pointes reported in man."
15711592
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"Pentamidine reduces hERG expression to prolong the QT interval."
20547773
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"Decreased levels of mature hERG expression are one of the life-threatening side effects of pentamidine and the major trigger of Torsade de Pointes arrhythmias."
35540224
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"cardiac glycosides, arsenic trioxide, pentamidine, and ketoconazole) ( Ficker et al., 2004; Kuryshev et al., 2005; Takemasa et al., 2008; Wang et al., 2007 ) reduced hERG membrane expression by inhibi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27575519
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"Pentamidine, was shown to inhibit the expression of hERG in the membrane, without acute effects on voltage-dependent ion channels or the action potential waveform ( Cordes et al., 2005; Kuryshev et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23538024
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"cardiac glycosides, arsenic trioxide, pentamidine, probucol and ketoconazole) ( Wang et al., 2007; Ficker et al., 2004; Kuryshev et al., 2005; Guo et al., 2007; Takemasa et al., 2008 ) reduce hERG sur[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20951697
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"Pentamidine reduces hERG expression to prolong the QT interval."
15711592