IndraLab

Statements

TRIM11 inhibits USP14. 3 / 3
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"11) strongly reduced the deubiquitinase activity in the control lysates, and rendered TRIM11 ineffective in reducing deubiquitinase activity, indicating that TRIM11 specifically inhibits the deubiquitinase activity of USP14."
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"Together, these results show that TRIM11 inhibits the association of USP14 with PSMD2, preventing it from docking on the proteasome."
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"By displacing USP14, TRIM11 changes proteasome composition and suppresses both catalytic and non catalytic effects of USP14."
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