IndraLab

Statements

COPS6 increases the amount of CTSL. 7 / 7
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"We further demonstrated that CSN6 positively regulated CTSL expression through an autophagy-lysosomal system."
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"In addition, CSN6 could up-regulate the expression of CTSL by inhibiting autophagy, thereby promoting the migration and invasion of CC cells."
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"CSN6 interacts with CTSL and positively regulates CTSL expression through an autophagy-lysosomal system."
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"These results suggested that CSN6 increased steady-state expression of CTSL in an autophagy-lysosomal dependent manner."
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"Furthermore, knockdown of CSN6 suppressed CTSL expression and the cell invasion ability of the CC cells."
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"CSN6 could increase steady-state expression of CTSL through preventing autophagy-lysosomal system."
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"For instance, Zhang et al[24] revealed that the COPS6-UBR5-CDK9 axis could control melanoma proliferation and metastasis, while Mao et al[25] found that COPS6 could promote migration and invasion of cervical cancer cells by regulating the expression level of cathepsin L through the autophagy-lysosomal system."
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