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USP12 activates PHLPP1. 2 / 3

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"On the other hand, USP12 can also stabilize AR proteins and enhance their transcriptional activity by stabilizing the AKT (protein kinase B) dephosphorylases (PHLPP and PHLPPL) (McClurg et al., 2014)."

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"In fact, overexpression of WDR48 and USP12 induced apoptosis similarly to PHLPP1."

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USP12 activates PHLPP1. 2 / 3

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