IndraLab

Statements

OTUB1 inhibits TNF. 2 / 2
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"As shown in Fig. 2a, b, OTUB1-deficient BMDCs produced significantly less IL-12, TNF, and IL-6 after stimulation with T. gondii, T. gondii lysate antigen (TLA), TgPFN (which all signal via MyD88 ) (Fig. 2a), and LPS (Fig. 2b)."
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"Interestingly, only canonical NF‐κB and MAPK signaling are affected by the downregulation of OTUB1, which temporarily (as the non-canonical pathway is still functional) lowers the volume of produced cytokines including TNFα [32, 52]."
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