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USP18 increases the amount of Interferon. 3 / 3
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"Moreover, USP16KO cells did not show changes in interferon-induced ISG15 and USP18 mRNA (SI Appendix, Fig. S3D), nor altered levels of the interferon-induced proteins RIG-I, MDA5, and USP18 (SI Appendix, Fig. S3E)."
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"Downregulation of USP18 induces the expression of interferon-response genes [28], which we observe in the present study (Fig. 3H)."
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"USP18 upregulates the expression and production of type I interferon following infection with Sendai virus (SeV) or Encephalomyocarditis virus (EMCV)."
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