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Paricalcitol inhibits TRAF3. 3 / 3
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"Paricalcitol also prevented the downregulation of TNF receptor-associated factor 3 (TRAF3) in human peripheral blood mononuclear cells, resulting in decreased noncanonical NFκB-mediated proinflammatory responses, an effect that was shown to be VDR-independent in VDR knockout mice [12]."
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"In VDR knockout mice with renal injury, paricalcitol prevented TRAF3 downregulation and NF- kappa B2 dependent gene upregulation, suggesting a VDR independent anti-inflammatory effect of paricalcitol."
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"In VDR knockout mice with renal injury , paricalcitol prevented TRAF3 downregulation and NF - kappa B2-dependent gene upregulation , suggesting a VDR-independent anti-inflammatory effect of paricalcitol ."
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