IndraLab

Statements

USP7 activates immune response. 6 / 6
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"USP7 reprogrammed tumor-associated macrophages and modulates anti-tumor immune response in lung cancer."
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"USP7 mediates cell cycle control, tumor growth, chemoresistance, and tumor immunity by regulating multiple cellular signaling pathways, including the p53 and Wnt pathways (33, 34)."
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"Moreover, Dai et al. indicated that the USP7 targeting could modulate the anti-tumor immune response as a result of the reprogramming of tumor-associated macrophages in lung cancer (Dai et al., 2020)."
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"Scientists have made significant advances in understanding how USP7 modulates cancer patients’ immune response in recent years."
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"Independently of its action on p53 , USP7 modulates various pathways in homeostasis or during oncogenesis by targeting a large panel of substrates involved in cell cycle , DNA damage response , immune response , signal transduction , neuronal differentiation , and epigenetic regulation [ 7 , 9 ] ."
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"Recent research has substantially advanced our understanding of how USP7 modulates the immune response in cancer patients."
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