IndraLab

Statements

OTUB2 activates NSCLC. 4 / 4
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"More importantly, OTUB2 promoted NSCLC progression, which was largely dependent on the direct binding to and deubiquitination of U2AF2, at least in NSCLC cells."
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"To investigate the functional roles of U2AF2 in OTUB2 mediated NSCLC progression, we knocked down endogenous U2AF2 via two independent siRNAs in A549 and H1299 cells."
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"Our current findings suggest that OTUB2 promotes NSCLC progression, which is largely dependent on U2AF2, at least in NSCLC cells."
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"Next, to elucidate the underlying mechanism by which OTUB2 promotes NSCLC progression, a co-immunoprecipitation assay using antibodies against HA was performed in both 293T cells transfected with HA tagged OTUB2 and control cells."
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