IndraLab

Statements

2-aminoethoxydiphenylborane inhibits NLRP3. 5 / 5
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"In addition, we found that the constitutive IL-1beta secretion from CAPS PBMCs was also substantially reduced by blockers of InsP 3 -mediated intracellular Ca 2+ signalling pathways, 2-APB and BAPTA-AM, (XREF_FIG and XREF_SUPPLEMENTARY), which can also inhibit NLRP3 inflammasome activation induced by ATP or extracellular Ca 2+ (XREF_FIG)."
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"Suppression of nigericin stimulated NLRP3 inflammasome signaling by BAPTA and 2-APB can be dissociated from perturbation of Ca 2+ signaling."
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"These findings demonstrate that 2-APB inhibits NLRP3 inflammasome signaling downstream of K + efflux signals and independently of its canonical actions as an inhibitor of IP 3 R/SOCE mediated increases in [Ca 2+]."
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"While 2-APB blocks SOCE and inhibits NLRP3 inflammasome activation, these proteins have not been examined genetically in the context of NLRP3 activation."
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"Previous studies have demonstrated that 2-APB strongly inhibits NLRP3 inflammasome activation in response to nigericin and other stimuli."
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