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Amlexanox inhibits IRF3. 6 / 6
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"Conversely, amlexanox inhibited the activation of the IRF3 signalling pathway both in vivo and in vitro ."
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"In particular, pharmacological inhibition of IRF3 by Amlexanox inhibited the growth of tumor cells with YAP hyperactivation."
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"Treatment with amlexanox that decreases the activity of IRF3, significantly suppresses YAP-driven gastric cancer growth in mice."
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"IRF3 enhanced the YAP1-TEAD4 complex interaction to increase YAP1 activity, whereas the blockade of IRF3 by amlexanox abolished GC growth [39]."
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"Recently, we discovered that IRF3, a central transcription factor in antiviral innate immunity, acts as an agonist of YAP-TEAD in gastric cancer and that pharmacological inhibition of IRF3 by amlexanox suppresses YAP-driven gastric tumor growth ."
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"In line with these studies, strongly increased phosphorylation of IRF3 was observed in PA-stimulated hepatocytes, while amlexanox treatment significantly inhibited the activation of IRF3 in hepatocyte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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