IndraLab

Statements

Amlexanox inhibits IRF3. 3 / 3
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"In particular, pharmacological inhibition of IRF3 by Amlexanox inhibited the growth of tumor cells with YAP hyperactivation."
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"Treatment with amlexanox that decreases the activity of IRF3, significantly suppresses YAP-driven gastric cancer growth in mice."
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"Taken together, our findings show that treatment of amlexanox attenuated the severity of PA induced hepatotoxicity in vitro and lipoapoptosis by the inhibition of TBK1 and IKKepsilon-NF-kappaB and/or IRF3 pathway in hepatocytes and KCs."
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