IndraLab

Statements

Hydroxychloroquine inhibits chb. 20 / 20
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"HCQ may reduce the odds of CHB occurrence in fetuses exposed to maternal anti-Ro and SSA antibodies, especially in mothers who already had a child with CHB."
27457513
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"Conclusions:. These prospective data support that HCQ significantly reduces the recurrence of CHB below the historical rate by more than 50%, suggesting that this drug be prescribed for secondary prevention of fetal cardiac disease in anti-SSA/Ro-exposed pregnancies."
32674792
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"The next open-label multicenter trial [32] supported that HCQ significantly reduces CHB recurrence below the historical rate by >50%, suggesting that this drug should be prescribed for the secondary prevention of fetal cardiac disease in antiSSA/Ro-exposed pregnancies."
39064600
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"Thus, given biologic plausibility and observational data, a Phase II study was initiated to address whether HCQ reduces the recurrence of CHB below the historical rate of 18% (14)."
32674792
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"In conclusion, data from this prospective single-arm clinical trial support that HCQ reduces the recurrence of CHB in anti-SSA/Ro exposed pregnancies by more than half and should be considered for secondary prevention."
32674792
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"It has been proposed that maternal hydroxychloroquine treatment can prevent CHB and may provide a molecular basis for such a potential protective effect [32]."
37189582
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"These results suggest that hydroxychloroquine be prescribed to prevent the recurrence of CHB."
| PMC
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"It is recommended that HCQ treatment should be started between the 6th and 10th gestational weeks at a dose of 400 mg orally once a day [13,84], and an early treatment with HCQ decreases the recurrence of CHB by >50% [66]."
38791261
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"Izmirly et al. in a retrospective study firstly highlighted that HCQ significantly decreased the occurrence of CHB in patients having a previous affected child."
33415090
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"In this paper, they saw that HCQ significantly reduced the recurrence of CHB by >50%."
38939855
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"This case illustrates that HCQ does not invariably prevent CHB and is consistent with the clinical observation that this approach will not be effective in all anti-SSA/Ro exposed foetuses."
28598777
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"Preventative therapy with hydroxychloroquine (HCQ) reduces the recurrence rate of CHB in subsequent pregnancies by ~50%."
36686025
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"It was reported that sustained use of hydroxychloroquine could significantly reduce the risk of CHB and neonatal lupus syndromes."
39039448
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"In the following cohort study, HCQ use lowered the recurrence rate of CHB by 60% [34]."
36686025
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"Hydroxychloroquine has been proposed to reduce neonatal morbidity and the recurrence risk of CHB XREF_BIBR in patients with SLE."
28955500
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"A retrospective review of several large databases suggests that hydroxychloroquine use during pregnancy may decrease the risk of CHB."
20089705
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"New clinical trials are in progress for the prevention of CHB by HCQ and/or IVIG [60] ."
25555818
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"HCQ may reduce the odds of CHB occurrence in fetuses exposed to maternal anti-Ro and SSA Ab, especially in mothers who have already had a child with congenital heart block [XREF_BIBR]."
28386140
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"HCQ significantly reduces the recurrence rate of CHB in women who previously delivered an affected infant, with a protective effect exceeding 50% [18,88]."
40066690
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"While a small observational study suggests that hydroxychloroquine may partially prevent CHB in connective tissue disease patients, conflicting evidence exists regarding effective treatment."
37781682