IndraLab

Statements

KCNH2 decreases the amount of Cyclin. 4 / 4
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"We have previously shown that, acute stimulation of hERG1 ion channels in breast cancer cells promotes reduction (60%) of cyclin E2 protein level, whereas chronic stimulation down-regulated other cell cycle regulators [XREF_BIBR]."
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"Stimulation of hERG1 channel activity selectively down-regulates cyclin E2 protein level."
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"Interestingly, our experiments showed that stimulation of hERG1 channel dramatically reduced cyclin E2 protein level in Trastuzumab resistant SKBr3 cells as well."
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"In contrast, we observed that cyclin E2 protein level was significantly reduced after only 2 hours of drug treatment, indicating that acute hERG1 channel activation inhibits cyclin E2 protein expression in a manner that is distinct from the chronic effects exerted on other cell cycle regulators."
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