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USP5 inhibits TP53. 14 / 15
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"Similarly, the COPS2, COPS3, and USP5 which may degrade p53 were significantly upregulated in OCHA L compared to OTCS H (XREF_TABLE)."
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"However, silencing of USP5 significantly prolonged the p53 protein half-life (Fig. 3a), indicating that USP5 regulates p53 protein stability.We next investigated whether p53 is required for USP5 knockdown-induced cellular senescence."
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"Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53."
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"Activation of p53 can be accounted for by the ability of USP5 suppression to inhibit the proteasomal degradation of p53 without affecting the degradation of Mdm2."
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"XREF_BIBR, XREF_BIBR Further, Dayal et al reported that isopeptidase T inhibition causes both p53 activation and unanchored polyubiquitin chain accumulation."
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"Usp5 KD consistently led to p53 induction and accumulation of ubiquitinated p53 adducts while Usp5 overexpression diminished p53 content."
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"In another study, Zheng et al. demonstrated that inhibition of USP5 in non-small cell lung cancer can cause DNA damage while modulating the transcriptional activity of p53 [19]."
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"Importantly, silencing of USP5 dramatically blocks Kras -driven tumor growth in mice models, in which silencing of USP5-induced p53-dependent senescence burden plays a key role."
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"Recently, it has been shown that Usp5 knockdown induces p53 activation [XREF_BIBR], and Usp5 controls activation of apoptotic signaling as well as Jun N-Terminal kinase pathway during eye development [XREF_BIBR]."
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"Previous study has shown that Usp5 knockdown promoted p53 activation, so we suppose that Usp5 may be involved in carcinogenesis."
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"USP4 and USP5 inhibit p53 expression , but the molecular mechanism has yet to be elucidated [ 47-49 ] ."
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"Furthermore, recent studies have demonstrated that USP5 inhibition enhances the stability of p53, thus playing important roles in many tumor events including hepatocellular carcinoma [5] , melanoma [6[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Suppression of the human USP5 gene also causes the accumulation of unanchored polyubiquitins and enhances the intracellular level of p53 [XREF_BIBR]."
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"Ablation of pro-autophagy USP5 downregulates Beclin 1 to upregulate p53 and cellular senescence in the suppression of lung tumor growth."
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