IndraLab

Statements

USP5 inhibits TP53. 9 / 10
| 1 8
reach
"Suppression of the human USP5 gene also causes the accumulation of unanchored polyubiquitins and enhances the intracellular level of p53 [XREF_BIBR]."
25806519
reach
"Activation of p53 can be accounted for by the ability of USP5 suppression to inhibit the proteasomal degradation of p53 without affecting the degradation of Mdm2."
23712866
eidos
"USP4 and USP5 inhibit p53 expression , but the molecular mechanism has yet to be elucidated [ 47-49 ] ."
31133011
reach
"Similarly, the COPS2, COPS3, and USP5 which may degrade p53 were significantly upregulated in OCHA L compared to OTCS H (XREF_TABLE)."
27057169
reach
"Recently, it has been shown that Usp5 knockdown induces p53 activation [XREF_BIBR], and Usp5 controls activation of apoptotic signaling as well as Jun N-Terminal kinase pathway during eye development [XREF_BIBR]."
28881591
reach
"Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53."
19098288
reach
"Usp5 KD consistently led to p53 induction and accumulation of ubiquitinated p53 adducts while Usp5 overexpression diminished p53 content."
24980819
reach
"XREF_BIBR, XREF_BIBR Further, Dayal et al reported that isopeptidase T inhibition causes both p53 activation and unanchored polyubiquitin chain accumulation."
23375434
reach
"Previous study has shown that Usp5 knockdown promoted p53 activation, so we suppose that Usp5 may be involved in carcinogenesis."
28881591