IndraLab

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Gabapentin activates KCNQ3. 4 / 4
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"Gabapentin activation of KCNQ2/3 (EC50 = 4.2 nM) or homomeric KCNQ3* (EC50 = 5.3 nM) channels requires KCNQ3-W265, a conserved tryptophan in KCNQ3 transmembrane segment 5."
30021858
dgi
No evidence text available
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"The data suggest that synergy between 2FPG and 3FMSG arises from them each preferentially activating a different isoform within the KCNQ2/3 complex.We previously found that gabapentin is a potent activator of KCNQ3 and KCNQ5 but not KCNQ2 channels, and that it also activates KCNQ2/3 heteromers ."
31701029
reach
"Here, we report that gabapentin is a potent activator of the heteromeric KCNQ2/3 voltage-gated potassium channel, the primary molecular correlate of the neuronal M-current, and also homomeric KCNQ3 and KCNQ5 channels."
30021858