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USP2 activates PPARG. 2 / 2
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"In contrast, USP2 deficiency also decreased peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC1alpha) protein in C2C12 cells, while it upregulated Ppargc1a mRNA."

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"We also observed that adenovirus-mediated Usp2 (AdUsp2) overexpression increased PPAR-γ, GLUT4, and IRS1 expression under TNF-α stimulation (Fig. 5F)."