IndraLab

Statements

IFIH1 binds USP8. 3 / 3
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"Moreover, we found that AKT1 not only interacted with USP8 and MDA5 but also enhanced the interaction between USP8 and MDA5 in a dose‐dependent manner (Figure  xref ; Figure xref , Supporting Information)."
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"Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic target for autoimmune disorders linked to aberrant MDA5 activation."
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"We then examined the association between USP8 and MDA5 and found that USP8 specifically interacted with MDA5 but not with other related proteins, such as RIG‐I (Figure  xref ; Figure xref , Supporting Information), and that their association was potentiated after EMCV infection, but not Poly(I:C) HMW (Figure  xref ; Figure xref , Supporting Information)."
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