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USP37 deubiquitinates CDT1. 7 / 7
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"USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication."
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"USP37 regulates DNA replication by deubiquitinating CDT1, an important protein in DNA replication, but USP37 may control many unknown factors at replication forks that should be further explored [48]."
| PMC
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"The role of cysteine 350 in USP37 was first illustrated by Huang et al. in 2011, in which they found that CDK2 activates USP37 to antagonize APC (CDH1) and promote S phase entry and that USP37 deubiquitinates CDT1 [19]."
| PMC
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"USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication."
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"USP37 induces deubiquitination of CDT1, whereas a catalytically inactive (C350S) USP37 mutant is unable to ubiquitinate CDT1, further suggesting that USP37 plays a role in CDT1 stabilization."
| PMC
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"USP37 interacted with and deubiquitinated CDT1 to protect it from proteasomal degradation."
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"USP37 interacts with Cdt1 and is able to de-ubiquitinate Cdt1 invivo and, USP37 is able to regulate the loading of MCM complexes onto the chromatin."
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