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USP4 activates IRF8. 2 / 2

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"Deconjugation of polyubiquitin chains from IRF8 mediated by USP4 is vital for maintaining the function of regulatory T cells, which negatively regulate many different immune reactions."

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"USP4 interacts and positively regulates IRF8 function via K48 linked deubiquitination in regulatory T cells."

28477415

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IndraLab

Statements

USP4 activates IRF8. 2 / 2

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