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BAP1 binds PBRM1. 39 / 39
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"BAP1 -mutant tumors and PBRM1 -mutant tumors are also associated with different outcomes in patients ( xref )."
23832661
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"Complementing the analysis of the clinical significance of mutations in PBRM1 and BAP1 in ccRCC, multiple groups, including ours, assessed the association of PBRM1 and BAP1 protein expression with clinical outcomes."
26300218
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"However, how those lncRNAs are interacting with PBRM1 and BAP1 remains to be explored."
27340923
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"With first-line everolimus, PBRM1 and BAP1 mutations were associated with longer (median [95% confidence interval {CI}] 12.8 [8.1, 18.4] vs 5.5 [3.1, 8.4] mo) and shorter (median [95% CI] 4.9 [2.9, 8.1] vs 10.5 [7.3, 12.9] mo) PFS1L, respectively."
27751729
sparser
"The association of a PBRM1 or BAP1 mutation with better or worse PFS1L, respectively, with everolimus is surprising because higher mTORC1 activity was reported for patients with BAP1 versus PBRM1 mutant ccRCC [ xref ]."
27751729
sparser
"BAP1 and PBRM1 mutations are associated with characteristic and non-overlapping gene expression signatures, and outcomes for patients with ccRCCs mutated in BAP1 or PBRM1 are different [ xref ]."
28812986
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"These data provide evidence of negative selection of PBRM1− BAP1− tumors consistent with negative genetic interaction between PBRM1 and BAP1."
26300218
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"Genetically, a previous report suggests that combined loss of BAP1 and PBRM1 may be associated with rhabdoid morphology."
26017874
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"We previously validated IHC assays with Sanger sequencing to evaluate PBRM1 and BAP1 protein expression in which negative nuclear staining associates with PBRM1 and BAP1 mutations. xref , xref We used background stroma and lymphocyte nuclei as a positive control, and therefore, we excluded from our analysis samples that lacked stroma/lymphocyte nuclear staining, focal negative or weak positive staining in these cells ( xref )."
25465300
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"While PBRM1 and BAP1 expression have been preliminarily associated with prognostic outcome, their predictive utility remains unclear. xref However, compelling data regarding the predictive utility of KDM5C mutation have recently been presented."
27099525
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"Similarly, the chromatin accessibility changes associated with the chromatin modifiers BAP1 and PBRM1 described in this manuscript will benefit from additional epigenetic assays such as ChIP-seq and transposase-directed transposon insertion mapping to ascertain the direct effect of BAP1 and PBRM1 on the candidate affected genes."
36973268
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"Although previous studies have demonstrated that BAP1 and PBRM1 mutations are associated with poor prognosis [11,18–20] , most of those studies used samples from the primary tumor in patients wit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28284891
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"In particular PBRM1− BAP1− tumors were associated with aggressive features."
26300218
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"The association between VHL, PBRM1, BAP1, SETD2 AND KDM5C mutation status and overall survival was evaluated in 167 patients with metastatic ccRCC who underwent genomic sequencing of their primary tumor."
31313716
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"Given the association between BAP1 and PBRM1 with nuclear grade , it is not surprising that BAP1- and PBRM1-deficient tumors are associated with different outcomes in patients."
35932824
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"All three genes are located on chromosome 3p, as is VHL and as noted earlier, inactivation of both VHL and Bap1 in mice leads to both cystic and neoplastic lesions [86]; clearly, definition of the functional interactions between VHL, BAP1, PBRM1, and SET is a topic of urgent interest."
25870008
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"Notably, SETD2-PBRM1 was the most frequently co-occurring mutation pair, whereas BAP1-PBRM1 displayed mutual exclusivity (Supplementary Fig. 7D)."
40016772
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"Finally and perhaps most importantly, despite the unknown biological rationale of the genetic interaction between PBRM1 and BAP1 we conclude that these data support the simultaneous analysis of PBRM1 and BAP1."
26300218
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"Ongoing investigation is needed to determine the clinical significance of additional mutations in ccRCC and whether PBRM1 or BAP1 expression is associated with the response to currently available therapies for ccRCC."
26300218
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"Interestingly, BAP1 and PBRM1 mutations anticorrelate in tumors ( P =3×10 −5 ), and combined loss of BAP1 and PBRM1 in a few RCCs was associated with rhabdoid features ( q =0.0007)."
22683710
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"Interestingly, in addition to M and grade, mutations in BAP1 and PBRM1 were independently associated with OS in the TCGA cohort (HR, 2.3; 95% CI, 1.03-5.1; p =0.041) ( xref )."
23333114
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"BAP1 -mutant tumors are associated with significantly worse overall survival than PBRM1 -mutant tumors (median OS in UTSW of 4.6 vs. 10.6 years; p= 0.044)."
23333114
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"The nearly identical HR and statistically significant p values in two representative and independent patient cohorts strongly supports the conclusion that BAP1- and PBRM1 -mutated tumors are associated with distinct survival outcomes."
23333114
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"We observed a negative genetic interaction between BAP1 and PBRM1, confirming a result that was reported previously [XREF_BIBR]."
28327121
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"Gerlinger and colleagues have shown that intragenic VHL mutations and loss of 3p are the only uniformly truncal events in ccRCC.( xref ) We have shown that loss of PBRM1 and BAP1 are mutually exclusive and that loss of PBRM1 is associated with better outcomes than loss of BAP1.( xref , xref , xref ) Herein we validate previous results from a meta-analysis showing that PBRM1 and SETD2 mutations cooperate in ccRCC.( xref ) Specifically, we find that H3K36me3 loss is 3 times more likely in PBRM1-negative tumors than in those that express PBRM1."
26516698
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"However, substantial recombination rates were observed ( xref ) and the recombination events were associated with loss of Bap1 and Pbrm1 ( xref ) and activation of downstream Vhl targets such as CAIX ( xref )."
28473526
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"Germline mutations in BAP1 and PBRM1 have been associated with ccRCC familial syndromes, but these mutations are rare and BAP1 germline mutations are primarily associated with other tumor types such as melanoma and mesothelioma ( xref – xref )."
28473526
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"In addition, BAP1-deficient tumors are associated with significantly worse patient survival than PBRM1-deficient tumors ( xref , xref , xref – xref )."
28473526
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"These data provide evidence of negative selection of PBRM1- BAP1- tumors consistent with negative genetic interaction between PBRM1 and BAP1."
26300218
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"Kaplan-Meier and Cox regression models were used to evaluate association of PBRM1 and BAP1 expression with the risk of death from renal cell carcinoma and the risk of metastasis after adjustment for age and the Mayo Clinic SSIGN (stage, size, grade and necrosis) score."
26300218
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"We show that 70% of ccRCCs lose either BAP1 or PBRM1, that tumors tend to segregate into BAP1 or PBRM1-deficient subtypes, and that BAP1 loss but not PBRM1 loss is associated with high tumor grade."
22683710
sparser
"We observed a negative genetic interaction between BAP1 and PBRM1, confirming a result that was reported previously [ xref ]."
28327121
reach
"Finally and perhaps most importantly, despite the unknown biological rationale of the genetic interaction between PBRM1 and BAP1 we conclude that these data support the simultaneous analysis of PBRM1 and BAP1."
26300218
sparser
"GAs in the chromatin modulating genes, BAP1 and PBRM1 were associated with bone metastases and worse survival in extrahepatic CCA."
25536104
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"Mutations in some of these genes, such as PBRM1 and BAP1 in RCC, are associated with poor patient outcome (Joseph et al ., xref ; Pawlowski et al ., xref ), indicating that their downstream pathways may also contribute to cancer progression and metastasis."
27756687
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"Clear cell renal cell carcinoma (ccRCC) is characterized by BAP1 and PBRM1 mutation, which are associated with tumors of different grade and prognosis."
28473526
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"In pleural and peritoneal mesothelioma, co-occurring alterations occurred on the same chromosome or in close proximity for PBRM1–BAP1 (both 3p21) and SETD2–BAP1 (both 3p21), which was observed in the TCGA cohort but not in the recent publication by Zauderer and colleagues [ xref ]."
36138075
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"After SETD2, the polybromo 1 (PBRM1) and the BRCA1 associated protein-1 (BAP1) genes were discovered."
32947307
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"These data show that BAP1 -mutated tumors are associated with significantly worse OS than PBRM1 -mutated tumors."
23333114